Joana Loureiro

Junior Researcher

Research group: Supramolecular Assemblies

Background: PhD in Chemical and Biological Engineering from the University of Porto, Portugal

Major research topics

• Functionalized nano-drug delivery systems for therapeutic applications

• Conformational studies of amyloidogenic peptides

• Design and production of lipid and polymeric nanoparticles to target the blood brain barrier

• Interaction studies of therapeutic molecules with biological membranes mimics

Selected Publications

Fonseca-Gomes J, Loureiro JA, Tanqueiro SR, Mouro FM, Ruivo P, Carvalho T, Sebastião AM, Diogénes MJ, Pereira MC, In vivo bio-distribution and toxicity evaluation of polymeric and lipid-based nanoparticles: a potential approach for chronic diseases treatment, in International Journal of Nanomedicine,2020

Andrade S, Ramalho MJ, Loureiro JA, Pereira MC. Interaction of Natural Compounds with Biomembrane Models: A Biophysical Approach for the Alzheimer's Disease Therapy. Colloids and Surfaces B: Biointerfaces, 2019.

Loureiro JA, Andrade S, Duarte A, Neves AR, Queiroz JF, Nunes C, Sevin E, Fenart L, Gosselet F, Coelho MAN, Pereira MC. Resveratrol and grape extract-loaded solid lipid nanoparticles for the treatment of Alzheimer's disease. Molecules, Vol. 2, Pages 1-16, 2017

Loureiro JA, Gomes B, Rocha S, Coelho MA Pereira MC. Cellular uptake of PLGA nanoparticles targeted with anti-amyloid and anti-transferrin receptor antibodies for Alzheimer's disease treatment. Colloids and Surfaces B: Biointerfaces, Vol. 145, Pages 8-13, 2016

Loureiro JA, Crespo R, Börner H, Martins PM, Rocha FA, Coelho MA, Pereira MC, Rocha S. Fluorinated beta-sheet breaker peptides. Journal of Materials Chemistry B, Vol. 2, Pages 2259-2264, 2014

Selected Projects

“New therapeutic strategy and new biomarker for Alzheimer's disease based on cleavage of the BDNF receptor” (MB-37-2017). Beginning: 2018. Duration 36 months. Role: Researcher.

"NANOEFEct - Nanoparticle-Enhanced Molecular Fluorescence-endoscopy for Detection of Early-stage Colorectal Adenocarcinomas" (ERA-NET: CANCER12-FP-052). Beginning: 2014. Duration 36 months. Role: Researcher.

"Antibody-directed Liposomes for Alzheimer’s Disease" (PTDC/QUI-BIQ/118076/2010) Beginning: 2012. Duration 36 months. Role: Researcher.

"Design and Biological Activity of Fluorinated Peptides on the Amyloid Beta-Peptide Aggregation" (PTDC/QUI-BIQ/102827/2008) Beginning: 2010. Role: Researcher.