Manuel Neto Coelho

Senior Researcher

Member of the Scientific Steering Committee

Research group: Supramolecular Assemblies and Proceses Systems Engineering

Academic position: Assistant Professor (FEUP)

Background: PhD in Chemical Engineering – Faculty of Engineering of Porto, Portugal

Major research topics

• Nanocapsules and nanoparticles with functionalized surfaces.
• Nanoparticle biocompatibility, nanoparticle/drug cell uptake mechanisms, interaction with proteins.
• Functionalized gold nanoparticles for drug delivery; Cancer therapy.
• Beta-Amyloid Peptides; functionalized liposomes/nanoparticles to target the Blood Brain Barrier (BBB).
• Air pollutants /exposure risk assessment; Alzheimer disease.

Selected Publications

P. Juzenas, W. Chen, Y.P. Sun, M. A.N. Coelho, R. Generalov, N. Generalova, I.L. Christensen. Quantum dots and nanoparticles for photodynamic and radiation therapy of cancer Advanced Drug Delivery Reviews, (2008), 60, 600-1614

Coelho SC, Rocha S, Juzenas P, Sampaio P, Almeida GM, Silva FS, Pereira MC, Coelho MA Gold nanoparticle delivery-enhanced proteasome inhibitor effect in adenocarcinoma cells. Expert Opin Drug Deliv (2013) 10 (10), 1345-52.

Coelho SC, Rocha S, Carmo Pereira M, Juzenas P, Coelho MAN, Enhancing proteasome inhibitor effect by functionalized gold nanoparticles. J. Biomed. Nanotech. Volume 10, Number 4, (2014)  pp.717-723.

Coelho SC, Rangel M, Carmo Pereira M, Coelho MAN, Ivanova G, Structural characterization of functionalized gold nanoparticles for drug delivery in cancer therapy: a NMR based approach. Phys. Chem. Chem. Phys 17 (2015), 18971-18979.

Coelho SC, Carmo Pereira M, Juzeniene A, Juzenas P, Coelho MAN, Supramolecular Nanoscale Assemblies for Cancer Diagnosis and Therapy. Journal of Controlled Release (2015) 213, 152-167.