Sílvia Castro Coelho

Junior Researcher

Research group: Supramolecular Assemblies

Background: PhD in Chemical and Biological Engineering from the University of Porto, Portugal

Major research topics

• Gold nanoparticles
• Drug delivery systems
• Nano-engineered biomaterials
• Cancer therapy and diagnosis
• Nanoparticle/drug cell mechanisms uptake

Selected Publications

Coelho S. C., Reis D.P., Carmo Pereira M., Coelho M.A. Gold Nanoparticles for Targeting Varlitinib to Human Pancreatic Cancer Cells. Pharmaceutics (2018) 10(3), 91. doi.org/10.3390/pharmaceutics10030091

Coelho SC, Almeida GM, Carmo Pereira M, Santos-Silva F, Coelho MAN, Functionalized gold nanoparticles improve afatinib delivery into cancer cells, Expert Opinion on Drug Delivery (2016) 13(1):133-41. doi: 10.1517/17425247.2015.1083973

Coelho SC, Rangel M, Carmo Pereira M, Coelho MAN, Ivanova G, Structural characterization of functionalized gold nanoparticles for drug delivery in cancer therapy: a NMR based approach. Phys. Chem. Chem. Phys (2015) 17, 18971-18979. doi: 10.1039/C5CP02717A

Coelho SC, Carmo Pereira M, Juzeniene A, Juzenas P, Coelho MAN, Supramolecular Nanoscale Assemblies for Cancer Diagnosis and Therapy. Journal of Controlled Release (2015) 10;213:152-167. doi: 10.1016/j.jconrel.2015.06.034

Coelho SC, Rocha S, Carmo Pereira M, Juzenas P, Coelho MAN, Enhancing proteasome inhibitor effect by functionalized gold nanoparticles. J. Biomedical Nanotechnology (2014) 10:4. doi:10.1166/Jbn.2014.1743

Selected Projects

"Development of controlled delivery functional systems by microencapsulation of natural and active compounds with therapeutic, nutritional and technological interest" (POCI-01-0145-FEDER-028715), funded by FEDER funds through COMPETE2020 - Programa Operacional Competitividade e Internacionalização (POCI) and by national funds (PIDDAC) through FCT/MCTES. Beginning 2018. Duration 36 months.

“Nanoparticle enhanced molecular Fluorescence-Endoscopy for detection of early stage colorectal adenocarcinoma" (TRANSCAN/0001/2012 funded by FCT - Fundação para a Ciência e Tecnologia. Beginning 2014. Duration 40 months.

"Biomolecules delivery by functionalized inorganic/organic nanoparticles" (PTDC/QUI/BIQ/115449/2009) funded by FCT - Fundação para a Ciência e Tecnologia. Beginning 2011. Duration 42 months.